Lab & Pilot Scale Pharmaceutical Freeze Dryers

Cresco EngineersLab & Pilot Freeze Dryers21 CFR Part 11

Model: LyoMini Series

Lab & Pilot Scale Pharmaceutical Freeze Dryers

Name: Lab & Pilot Scale Pharmaceutical Freeze Dryers
Brand: Cresco Engineers

The LyoMini Series covers 6 models across 3 shelf sizes ranging from 0.12 m² to 1.01 m² shelf area. Designed for formulation scientists and pilot-scale R&D teams, LyoMini enables predictable cycle transfer to commercial production by sharing the exact engineering approach and control philosophies of full-scale LyoMega systems. Features electrically heated shelves with closed-loop control, -85 °C ice condensers, and full PLC touchscreen HMI with cycle programming and printed batch records.

Shelf Area0.12 – 1.01 m²

Condenser Temp−85 °C

Condenser Capacity6 – 40 kg

Pilot Shelf Range−60 to +80 °C

AISI 316L Contact Metallurgy21 CFR Part 11 SCADA OptionGAMP 5 Validation Ready

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Key Features

6 models across 3 shelf sizes: 0.12, 0.24, 0.40, 0.54, 0.81, and 1.01 m² shelf area
AISI 316L stainless steel chamber & shelves with mirror-finished product-contact surfaces
−85 °C ice condenser across all models with built-in defrost facility (6 to 40 kg capacity)
Shelf temperature control: −50 to +70 °C (bench models) / −60 to +80 °C (pilot models)
Oil-sealed rotary vacuum pump with isolation valve (12 to 36 m³/h capacity)
PLC with touchscreen HMI, recipe cycle programming, and printed batch record
Optional controlled nucleation with eutectic point detection for uniform ice crystal structure
Optional vial stoppering mechanism and external bottle manifold attachments

Technical Specifications

Model Technical Specifications

LyoMini 0.12 m²

Shelf: 200 × 300 mm (2 shelves) | Temp: −50 to +70 °C | Condenser: 6 kg @ −85 °C | Vacuum: 12 m³/h

LyoMini 0.24 m²

Shelf: 200 × 300 mm (4 shelves) | Temp: −50 to +70 °C | Condenser: 6 kg @ −85 °C | Vacuum: 12 m³/h

LyoMini 0.40 m²

Shelf: 300 × 450 mm (3 shelves) | Temp: −60 to +80 °C | Condenser: 30 kg @ −85 °C | Vacuum: 30 m³/h

LyoMini 0.54 m²

Shelf: 300 × 450 mm (4 shelves) | Temp: −60 to +80 °C | Condenser: 30 kg @ −85 °C | Vacuum: 30 m³/h

LyoMini 0.81 m²

Shelf: 450 × 450 mm (4 shelves) | Temp: −60 to +80 °C | Condenser: 40 kg @ −85 °C | Vacuum: 36 m³/h

LyoMini 1.01 m²

Shelf: 450 × 450 mm (5 shelves) | Temp: −60 to +80 °C | Condenser: 40 kg @ −85 °C | Vacuum: 36 m³/h

Standard Equipment

Chamber & Shelves

AISI 316L stainless steel with mirror-finished product-contact surfaces

Shelf Heating

Electrically heated shelves with closed-loop precision temperature control

Vacuum System

Oil-sealed rotary vacuum pump with isolation valve

Control System

PLC with touchscreen HMI, cycle programming, and printed batch record

Condenser Unit

Integrated ice condenser with defrost facility (−85 °C rating)

Optional Extras & Customization

Chamber Isolation Valve

Allows the condenser to be defrosted independently

Vial Stoppering

Vial stoppering mechanism and bottle manifold attachments

Clean-Room Front

Panelled front for installation in classified cleanroom areas

Nucleation Control

Eutectic point detection and controlled nucleation for uniform product

SCADA Software

Data recording, alarm management, audit trail, and remote connectivity

CIP / VHP

Clean-in-place circuit and VHP-compatible sanitisation

Shelf Spacing

Dual shelf-spacing configuration for taller containers

Solvent Condenser

Organic solvent condenser for non-aqueous formulations

Wireless Probes

Wireless temperature probes for flexible sensor placement

In-Process Sampling

Vial sampling device for non-invasive extraction

Pressure Sensing

Capacitive pressure sensor with comparative measurement to confirm end of drying

Available Models & Configurations

Model	Description
LyoMini-0.12	0.12 m² benchtop freeze dryer, 2 shelves (200 × 300 mm), 6 kg condenser
LyoMini-0.24	0.24 m² benchtop freeze dryer, 4 shelves (200 × 300 mm), 6 kg condenser
LyoMini-0.40	0.40 m² pilot freeze dryer, 3 shelves (300 × 450 mm), 30 kg condenser
LyoMini-0.54	0.54 m² pilot freeze dryer, 4 shelves (300 × 450 mm), 30 kg condenser
LyoMini-0.81	0.81 m² pilot freeze dryer, 4 shelves (450 × 450 mm), 40 kg condenser
LyoMini-1.01	1.01 m² pilot freeze dryer, 5 shelves (450 × 450 mm), 40 kg condenser

Request for Quotation & Engineering Data

Inquire About LyoMini Series

Need pricing, validation documentation (IQ/OQ), or custom application sizing? Contact our bioprocess engineering team.

Applications

Pharmaceutical recipe development
Biotech formulation trials
Technology transfer ahead of commercial scale-up
Small-batch clinical trial and R&D freeze-drying
Non-aqueous solvent lyophilization with optional solvent condenser

Calibration & Validation

ISO/IEC 17025 factory calibration certificates and IQ/OQ documentation packages are available on request.

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Documentation

Technical datasheets and user manuals are available from our engineering team upon request.

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Cresco Engineers21 CFR Part 11

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